New research suggests that the creatine supplement, popular among gym-goers, may assist in treating depression. Scientists at the University of Ottawa have indicated that creatine positively impacts mental health by enhancing the brain’s energy supply system. However, they caution that more extensive clinical trials are necessary, and safety considerations regarding creatine use must be observed.
Creatine, widely used by individuals who go to the gym and build muscle, has been shown in this new study to potentially support treatment for depression (depressive disorder). By stimulating the brain’s energy supply system, creatine may have a beneficial effect on mental health, according to researchers. Although current evidence is promising, further research is required before it can be recommended as a medicine in medical practice.
Published in the journal Brain Medicine, a systematic review conducted by researchers from the University of Ottawa analyzed five clinical trials conducted in various countries. These trials involved a total of 238 participants, many of whom were women. The study results were mixed. Two of the trials reported significant improvement in depression symptoms with creatine use, whereas the other three found no notable benefit.
One study, focused primarily on women with major depressive disorder, found that taking 5 grams of creatine daily alongside the conventional antidepressant escitalopram led to a marked reduction in depression symptoms within eight weeks, with many patients showing recovery. In contrast, the other three trials, which involved patients who did not respond to other medications, adolescents, and individuals with bipolar disorder, did not demonstrate a significant effect of creatine.
The primary mechanism by which creatine may combat depression is by replenishing the brain’s energy needs. Creatine accelerates the production of adenosine triphosphate (ATP), the energy currency, in brain cells similar to its role in muscles. Scientists also speculate that creatine may influence neurotransmitters that regulate mood, such as dopamine and serotonin. Experts emphasize the need for larger, long-term clinical trials involving more men and women to fully understand creatine’s role and efficacy in depression treatment.
